Klaus Linkenkaer-Hansen
Keynote speakers
- Kenji Doya
- Alon Halevy
- Astrid Prinz
- Andrew Schwartz
- Shankar Subramaniam
- Arthur Toga
Workshop speakers
- Bart ter Haar Romeny
- Uri Eden
- Klaus Linkenkaer-Hansen
- Tim Clark
- Alan Ruttenberg
- Jeffrey Grethe
- Arnd Roth
- Wulfram Gerstner
- Peter Hunter
- Markus Diesmann
- Andrey Semin
- Pietro Liò
- Albert Cardona
- Giorgio Ascoli
- Rolf Kötter
Workshop 1, Advances in the automatic analysis of multi-dimensional data
Klaus Linkenkaer-Hansen
Title: Complex fluctuations in neuronal oscillations: From a qualitative hallmark to disease-sensitive quantitative traits
VU University, Amsterdam, Netherlands
Abstract: Human brain oscillations fluctuate erratically in amplitude during rest and exhibit power-law decay of temporal correlations (Linkenkaer-Hansen et al., 2001). Recent progress in studying genetic (Linkenkaer-Hansen et al., 2007) and disease influences (Montez et al., 2009) of the complex temporal structure of ongoing oscillations, suggests that much information can be derived from time series analysis of ongoing activity, which is not detected with classical spectral methods. Some of the methods used to study the temporal structure are inspired by the statistical behavior of self-organizing complex systems near a critical state (Poil et al., 2008). In this talk, I will provide an introduction to the theoretical framework of critical dynamics in the context of spontaneous neuronal oscillations and give examples of how the quantitative tools developed on the back of this framework have helped us identify novel aspects of brain function in health and disease.
References
Linkenkaer-Hansen K, Nikouline VV, Palva JM, Ilmoniemi RJ (2001) Long-Range Temporal Correlations and Scaling Behavior in Human Brain Oscillations. J Neurosci 21:1370-1377.
Linkenkaer-Hansen K, Smit DJA, Barkil A, van Beijsterveldt TEM, Brussaard AB, Boomsma DI, van Ooyen A, de Geus EJC (2007) Genetic Contributions to Long-Range Temporal Correlations in Ongoing Oscillations. J Neurosci 27:13882-13889.
Montez T, Poil S-S, Jones BF, Manshanden I, Verbunt JPA, van Dijk BW, Brussaard AB, van Ooyen A, Stam CJ, Scheltens P, Linkenkaer-Hansen K (2009) Altered temporal correlations in parietal alpha and prefrontal theta oscillations in early-stage Alzheimer disease. Proceedings of the National Academy of Sciences 106:1614-1619.
Poil S-S, van Ooyen A, Linkenkaer-Hansen K (2008) Avalanche dynamics of human brain oscillations: Relation to critical branching processes and temporal correlations. Human Brain Mapping 29:770-777.
Bio sketch: Klaus Linkenkaer-Hansen is Assistant Professor in the Department of Integrative Neurophysiology at Center for Neurogenomics and Cognitive Research (CNCR) at VU University Amsterdam. He received his M.Sc. in Physics-biophysics from the Niels Bohr Institute (Copenhagen University, Denmark) in 1998. He received his PhD from Helsinki University of Technology (Finland) in 2002. Following post-doctoral fellowships at the Netherlands Institute for Brain Research and in the Neuroinformatics Group at CNCR, he became team leader of the research group Neuronal Oscillations and Cognition in 2008.
His research is focused on the complex dynamics of neuronal oscillations and its implications for cognition in health and disease. Theories and methods from the physics of self-organization and complexity have guided his multi-disciplinary research for more than 10 years, currently involving computational modelling, pharmacologically induced oscillations in vitro, genetic influences studied in twins, and altered oscillatory dynamics in different patient groups. His research has shown that the complex temporal structure of ongoing oscillations is rich in information about the functional state and structure of the underlying neuronal networks.